Belgian U21 | |||
| 2022-01-31 18:30:00 | RS Waasland Beveren U21 | 0 - 1 | Seraing U21 |
| 2022-01-31 18:30:00 | Kortrijk U21 | 2 - 3 | AS Eupen U21 |
| 2022-01-31 18:30:00 | Anderlecht U21 | 5 - 0 | St.-Truidense U21 |
| 2022-01-31 18:30:00 | Royal Antwerp FC U21 | 0 - 0 | KV Mechelen U21 |
| 2022-01-31 18:30:00 | Club Brugge U21 | 3 - 0 | Royal Charleroi U21 |
| 2022-01-31 18:30:00 | KAA GentU21 | 3 - 0 | Oud Heverlee Leuven U21 |
| 2022-01-31 18:30:00 | Cercle Brugge U21 | 2 - 3 | Racing Genk U21 |
| 2022-01-31 18:30:00 | Zulte-Waregem U21 | 1 - 1 | Standard Liege U21 |
| 2022-01-31 19:00:00 | Westerlo U21 | 3 - 5 | Excelsior Virton U21 |
| 2022-01-31 19:00:00 | Lommel SK U21 | 3 - 2 | RWD Molenbeek U21 |
| 2022-01-31 19:00:00 | Lierse U21 | 0 - 3 | St. Gilloise U21 |
| 2022-01-31 19:00:00 | Beerschot Wilrijk U21 | 3 - 3 | KV Oostende U21 |