AC Milan were hit hard in the new season’s first leg, they upset fans at home with an accidental loss to visitor, the newly promoted Sampdoria 0-1.

The visitor Sampdoria hasn’t beaten the Rossoneri since 2008, but this victory announced their return to the Serie A with momentum. AC Milan’s newcomer Pazzini came on from the bench in 56 minutes against his old club, but just a few minutes later, their opponent broke through to score by Andrea Costa’s header from corner. Though Boateng hit the post thereafter, but it failed to prevent Sampdoria’s final victory.

While Rossoneri's city rival Inter Milan’s opener was much better with a thrashing away 3-0 win against Pescara. Wesley Sneijder and Diego Milito each scored one in the first half, Coutinho then complete the scoring performances for Inter. Napoli also won by the same score, beating Palermo with all three points. Henaneisi's goal to help Lazio's 1-0 defeat away to Atlanta Lopez stoppage time goal to help Rome 2-2 draw with Catania. Hernanes gained a 1-0 opening win over Atalanta for Lazio and Nicolas Lopez grasped a 2-2 draw for AS Roma against Calcio Catania in added time.

Elsewhere, Genoa CFC saw beat Cagliari Calcio 2-0, AC Chievo Verona win over Bologna FC in the same score, and AC Siena and Torino FC ended the game with a 0-0 draw.